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Schulz, Eduard; Valentin, Angelika; Ulz, Peter; Beham-Schmid, Christine; Lind, Karin; Rupp, Verena; Lackner, Herwig; Wölfler, Albert; Zebisch, Armin; Olipitz, Werner; Geigl, Jochen; Berghold, Andrea; Speicher, Michael R.; Sill, Heinz (July 2012): Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms. In: Journal of medical genetics, Vol. 49, No. 7: pp. 422-428




Therapy related myeloid neoplasms (t-MNs) are complex diseases originating from an interplay between exogenous toxicities and a susceptible organism. It has been hypothesised that in a subset of cases t-MNs develop in the context of hereditary cancer predisposition syndromes.