Wiedemann, Tobias; Hofbaur, Stefan; Tegtmeyer, Nicole; Huber, Sylwia; Sewald, Norbert; Wessler, Silja; Backert, Steffen; Rieder, Gabriele
Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex.
In: Gut, Vol. 61, Nr. 7: S. 986-996
One of the most important hormones in the human stomach is the peptide gastrin. It is mainly required for the regulation of gastric pH but is also involved in growth and differentiation of gastric epithelial cells. In Helicobacter pylori infected patients, gastrin secretion can be upregulated by the pathogen, resulting in hypergastrinaemia. H pylori induced hypergastrinaemia is described as being a major risk factor for the development of gastric adenocarcinoma.