Synthesis and properties of a Cu(ii) complexing pyrazole ligandoside in DNA

Su, Meng; Tomas-Gamasa, Maria; Serdjukow, Sascha; Mayer, P. and Carell, Thomas (1. November 2013): Synthesis and properties of a Cu(ii) complexing pyrazole ligandoside in DNA. In: Chemical communications, Vol. 50, No. 4: pp. 409-411

Abstract

The development of metal base pairs is of immense importance for the construction of DNA nanostructures. Here we report the synthesis of a biaryl pyrazole-phenol nucleoside that forms in DNA a stable self-pair upon complexation of a Cu(ii) ion. A sequence with five consecutive pyrazole nucleotides allows the complexation of five Cu(ii) ions in a row.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1359-7345
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Annotation: First published online. Print publ. 2014
• Language: English