Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

Rullo, A.; Reiner, A.; Reiter, Alwin; Trauner, Dirk; Isacoff, E. Y. and Woolley, G. A. (6. October 2014): Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative. In: Chemical Communications, Vol. 50, No. 93: pp. 14613-14615

Abstract

A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1359-7345
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English