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Benjdia, Alhosna; Heil, Korbinian; Winkler, Andreas; Carell, Thomas; Schlichting, Ilme (19. September 2014): Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase. In: Chemical Communications, Vol. 50, Nr. 91: S. 14201-14204




The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.