Mixed sugar-core-phosphate chelation of D-fructose 1,6-bisphosphate with the (ReO)-O-V(tmen) metal fragment

Steinborn, Martin; Suhanji, Mihael und Kluefers, Peter (Februar 2013): Mixed sugar-core-phosphate chelation of D-fructose 1,6-bisphosphate with the (ReO)-O-V(tmen) metal fragment. In: Dalton Transactions, Bd. 42, Nr. 16: S. 5749-5754

Abstract

Sugar phosphates provide metal-binding sites both at their sugar core and at their phosphate group(s). Mixed sugar-core-phosphate chelation has been considered as a typical bonding mode within the physiological pH range for the central metabolite D-fructose 1,6-bisphosphate. The (ReO)-O-V(tmen) metal fragment was used to enrich this coordination type. The formation of the ReO(tmen)(Fruf2,3H(-2)1,6-P2H2-kappa O-3(2,3,P1))](-) monoanion was determined by NMR spectroscopy and mass spectrometry. The model compound rac-glycerol 1-phosphate yielded similar results in terms of NMR spectroscopy. Crystal-structure analyses of ReO(tmen)(rac-Glyc2,3H(-2)1PH-kappa O-3(2,3,P))]center dot 2H(2)O and ReO(phen)(rac-Glyc2,3H(-2)1PH-kappa O-3(2,3,P))]center dot MeOH confirmed the coordination pattern.

• Dokumententyp: Zeitschriftenartikel
• Publikationsform: Publisher's Version
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1477-9226
• Allianz-/Nationallizenz: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
• Sprache: Englisch