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Kneuttinger, Andrea Christa; Heil, Korbinian; Kashiwazaki, Gengo; Carell, Thomas (28. November 2012): The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair. In: Chemical Communications, Vol. 49, Nr. 7: S. 722-724




The spore photoproduct lyase is a radical SAM enzyme, which repairs 5-(alpha-thyminyl)-5,6-dihydrothymidine. Here we show that the enzyme establishes a complex radical transfer cascade and creates a cysteine and a tyrosyl radical dyade to establish repair. This allows the enzyme to solve topological and energetic problems associated with the radical based repair reaction.