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Baiker, Armin; Haase, Rudolf; Eberle, Josef; Pinto, Maria Guadalupe Vizoso; Pfrepper, Klaus-Ingmar; Petrich, Andreas; Deml, Ludwig; Campe, Hartmut; Nitschko, Hans; Jaeger, Gundula (2010): Early detection of Varicella-Zoster Virus (VZV)-specific T-cells before seroconversion in primary varicella infection: case report. In: Virology Journal 7:54


Here we report the case of a 54-year old, immunocompetent German patient with primary varicella whose Varicella-Zoster Virus (VZV)-specific T-cell responses could be detected early in infection and before the onset of seroconversion. This case demonstrates that the detection of VZV-specific T-cells may under certain circumstances support the diagnosis of a primary varicella infection, as for example in cases of atypical or subclinical varicella or in the absence of detectable VZV DNA in plasma.