Meiners, Silke; Eickelberg, Oliver: Next-generation personalized drug discovery: the tripeptide GHK hits center stage in chronic obstructive pulmonary disease. In: Genome Medicine 2012, 4:70




Chronic lung diseases (CLDs), including chronic obstructive pulmonary disease (COPD), are the second leading cause of death worldwide. The first report of database-driven drug discovery in carefully phenotyped COPD specimens has now been published in Genome Medicine, combining gene expression data in defined emphysematous areas with connectivity-map-based compound discovery. This joint effort may lead the way to novel and potentially more efficient concepts of personalized drug discovery for COPD in particular, and CLD in general.