Treatment with 4-aminopyridine improves upper limb tremor of a patient with multiple sclerosis: a video case report

Schniepp, Roman; Jakl, Veronika; Wühr, Max; Havla, Joachim; Kümpfel, Tania; Dieterich, Marianne; Strupp, Michael und Jahn, Klaus (April 2013): Treatment with 4-aminopyridine improves upper limb tremor of a patient with multiple sclerosis: a video case report. In: Multiple Sclerosis Journal, Bd. 19, Nr. 4: S. 506-508

Abstract

Here we report the case of a 44-year old patient with a progressive MS whose upper limb tremor was markedly reduced under treatment with 4-aminopyridine, as documented in a Tremor Activities of Daily Living questionnaire and in the 9-Hole Peg test. Hand accelerations decreased in the left hand from 10.9 m/sec2 to 2.2 m/sec2 and in the right hand from 4.2 m/sec2 to 0.9 m/sec(2). This case report indicates for the first time that 4-aminopyridine might be effective in the symptomatic treatment of tremor entities in patients with MS. The finding calls for further prospective studies to determine the usefulness of 4-aminopyridine or its sustained-release form dalfampridine in treating patients with tremor and MS.

• Dokumententyp: Zeitschriftenartikel
• Publikationsform: Publisher's Version
• Keywords: Postural tremor; 4-aminopyridine; cerebellar ataxia; multiple sclerosis; case study; tremor therapy
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1352-4585
• Allianz-/Nationallizenz: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
• Sprache: Englisch