Clinicians' Attitudes Toward the Use of Long-Acting Injectable Antipsychotics

Samalin, Ludovic; Charpeaud, Thomas; Blanc, Olivier; Heres, Stephan and Llorca, Pierre-Michel (July 2013): Clinicians' Attitudes Toward the Use of Long-Acting Injectable Antipsychotics. In: Journal of Nervous and Mental Disease, Vol. 201, No. 7: pp. 553-559

Abstract

Depot formulations are not widely used in everyday practice. This study aimed to assess psychiatrists' attitudes toward the use of long-acting injectable (LAI) antipsychotics in schizophrenia. We interviewed 113 French psychiatrists about the factors that influenced their prescription of LAI antipsychotics. Multidimensional and cluster analyses were used to detect correlations. The most important factor against the use of LAI antipsychotics is a sufficient estimated compliance with the oral formulation. For first-generation LAI, the main factor is the risk for extrapyramidal symptoms; and for second-generation LAI, it is the unavailability of the equivalent oral formulation. Four factors incite the psychiatrists to prescribe LAI. Two different clusters of patients can also be identified. Most factors influencing the clinicians' attitudes toward the use of LAI antipsychotics are shared in many countries. Conversely, some attitudes related to organizational aspects, particularly the relevance of health care costs, may vary from one country to another.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Keywords: Antipsychotics; long-acting injectable; attitudes; schizophrenia
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0022-3018
• Place of Publication: 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English