
Abstract
Background: The duration of protection after hepatitis B vaccination in early infancy is unclear and may be related to vaccination schedule, dosage, vaccine type and population characteristics. Factors potentially influencing waning immunity were assessed. Methods: A systematic review was performed. The main outcomes were prevalence of anti-hepatits B antibodies >= 10 mIU/mL after primary or booster vaccination. Factors potentially influencing protection were assessed in an adjusted random-effects meta-analysis model by age for both outcomes. Results of both meta-analyses were combined in a prognostic model. Results: Forty-six studies reporting on the anti-hepatits B antibodies >= 10 mIU/mL 5 to 20 years after primary immunization and 29 on booster response were identified. The adjusted meta-analyses identified maternal carrier status (odds ratio OR]: 2.37 1.11; 5.08]), lower vaccine dosage than presently recommended (OR: 0.14 0.06; 0.30]) and gap time between last and preceding dose of the primary vaccine series (OR: 0.44 0.22; 0.86]) as determinants for persistence of anti-hepatits B antibodies >= 10. A lower vaccine dosage was also associated with failure to respond to booster (OR: 0.20 0.10; 0.38]). The prognostic model predicted long-term protection of 90% 77%; 100%] at the age of 17 years for offspring of noncarrier mothers vaccinated with a presently recommended dose and vaccination schedule. Conclusions: Based on meta-analyses, predictors of waning immunity after hepatitis B vaccination in infancy could be identified. A prognostic model for long-term protection after hepatitis B vaccination in infancy was developed.
Item Type: | Journal article |
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Form of publication: | Publisher's Version |
Keywords: | hepatitis B; infant vaccination; booster; long-term protection; determinants of protection |
Faculties: | Medicine > Institute for Medical Information Processing, Biometry and Epidemiology |
Subjects: | 600 Technology > 610 Medicine and health |
URN: | urn:nbn:de:bvb:19-epub-24088-8 |
ISSN: | 0891-3668 |
Place of Publication: | 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA |
Alliance/National Licence: | This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. |
Language: | English |
Item ID: | 24088 |
Date Deposited: | 16. Mar 2015, 11:26 |
Last Modified: | 04. Nov 2020, 13:05 |