CELL-SELEX: Novel perspectives of aptamer-based therapeutics

Guo, Ke-Tai; Paul, Angela; Schichor, Christian; Ziemer, Gerhard und Wendel, Hans P. (April 2008): CELL-SELEX: Novel perspectives of aptamer-based therapeutics. In: International Journal of Molecular Sciences, Bd. 9, Nr. 4: S. 668-78

Abstract

Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.

• Dokumententyp: Zeitschriftenartikel
• Publikationsform: Publisher's Version
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1422-0067
• Sprache: Englisch