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Zoller, Michael; Maier, Barbara; Hornuss, Cyrill; Neugebauer, Christina; Döbbeler, Gundula; Nagel, Dorothea; Holdt, Lesca Miriam; Bruegel, Mathias; Weig, Thomas; Grabein, Béatrice; Frey, Lorenz; Teupser, Daniel; Vogeser, Michael; Zander, Johannes (2014): Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study. In: Critical Care 18:R148


Severe infections in intensive care patients show high morbidity and mortality rates. Linezolid is an antimicrobial drug frequently used in critically ill patients. Recent data indicates that there might be high variability of linezolid serum concentrations in intensive care patients receiving standard doses. This study was aimed to evaluate whether standard dosing of linezolid leads to therapeutic serum concentrations in critically ill patients.