Hypervolemia increases release of atrial natriuretic peptide and shedding of the endothelial glycocalyx

Chappell, Daniel; Bruegger, Dirk; Potzel, Julia; Jacob, Matthias; Brettner, Florian; Vogeser, Michael; Conzen, Peter; Becker, Bernhard F. und Rehm, Markus (2014): Hypervolemia increases release of atrial natriuretic peptide and shedding of the endothelial glycocalyx. In: Critical Care 18:538

Abstract

Acute normovolemic hemodilution (ANH) and volume loading (VL) are standard blood-sparing procedures. However, VL is associated with hypervolemia, which may cause tissue edema, cardiopulmonary complications and a prolonged hospital stay. The body reacts to hypervolemia with release of atrial natriuretic peptide (ANP) from the heart. ANP has been shown to deteriorate the endothelial glycocalyx, a vital part of the vascular permeability barrier. The aim of the present study was to evaluate and compare ANP release and damage to the glycocalyx during ANH and VL.

• Dokumententyp: Zeitschriftenartikel
• Publikationsform: Publisher's Version
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1466-609X
• Sprache: Englisch