Volz, Armin; Weiss, Elisabeth H.; Trowsdale, John; Ziegler, Andreas
(1994):
Presence of an expressed 13-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction.
In: Human Genetics, Vol. 93: pp. 42-46
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Abstract
An expressed beta-tubulin gene (TUBB) has previously
been localized to chromosome region 6pter-p21
in man. By using a panel of deletion mutant cell lines and
radiation-reduced hybrids containing fragments of chromosome
6, the TUBB locus could be mapped to the HLA
class I region at 6p21.3. A long range restriction map including
TUBB and several HLA class I genes was then
generated by rotating field gel electrophoresis. The results
show that TUBB maps to a segment 170-370 kb telomeric
of HLA-C. This location suggests that a mutation at the
TUBB locus could be the cause for certain forms of HLAlinked
microtubule dysfunction, including immotile cilia
syndrome.