Spengler, Ulrich; Möller, Achim; Jung, Maria C.; Messer, Gerald; Zachoval, Reinhard; Hoffmann, Robert M.; Eisenburg, Josef; Paumgartner, Gustav; Riethmüller, Gert; Weiss, Elisabeth H.
T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation.
In: Journal of Hepatology, Vol. 15: pp. 129-135
Primary biliary cirrhosis (PBC) is considered an autoimmune disease characterized by destruction of small intrahepatic
bile ducts by lymphocytes. Altered functions of these lymphocytes might reflect an abnormal immune response leading
to tissue damage. We investigated lymphokine secretion by mitogen-stimulated T lymphocytes from the liver biopsies
of patients with PBC and for comparison also peripheral blood. In PBC, diminished synthesis of lymphotoxin (TNFP),
tumor necrosis factor (TNFa) and interferon-y (IFIVy) was found both in T-cell lines from liver tissue and in peripheral
blood. The reduction was most prominent for TNFP in early histological stages of PBC, and appeared to be a stable
phenomenon when T cells were tested after long-term tissue culture. Analysis of mRNA levels indicates a possible link
between reduced TNFP production and a defect in interleukin-2 transcription. The data suggest that diminished
lymphokine production in patients with PBC may play ;In important role in the immanopathogenesis of this disease.