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Meruelo, Daniel; Kornreich, Ruth; Rossomando, Anthony; Pampeno, Christine; Boral, Anthony; Silver, Jack L.; Buxbaum, Joel; Weiss, Elisabeth H.; Devlin, J.; Mellor, Andrew L.; Flavell, Richard A. and Pellicer, Angel (1986): Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA. In: Proceedings of the National Academy of Science of the USA, Vol. 83: pp. 4504-4508 [PDF, 1MB]

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Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC DNA. These changes may play a role in host susceptibility to virus-induced leukemogenesis and accord with the notion that viral genomes play a regulatory function when they integrate adjacent to histocompatibiity genes.

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