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Meruelo, Daniel and Kornreich, Ruth and Rossomando, Anthony and Pampeno, Christine and Boral, Anthony and Silver, Jack L. and Buxbaum, Joel and Weiss, Elisabeth H. and Devlin, J. and Mellor, Andrew L. and Flavell, Richard A. and Pellicer, Angel (1986): Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA. In: Proceedings of the National Academy of Science of the USA, Vol. 83: pp. 4504-4508




Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC DNA. These changes may play a role in host susceptibility to virus-induced leukemogenesis and accord with the notion that viral genomes play a regulatory function when they integrate adjacent to histocompatibiity genes.