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Boshart, Michael; Nitsch, Doris and Schütz, Günther (1993): Extinction of gene expression in somatic cell hybrids. a reflection of important regulatory mechanisms? In: Trends in Genetics, Vol. 9, No. 7: pp. 240-245 [PDF, 720kB]


Extinction in somatic cell hybrids is a multifactorial process that leads to loss of cell-type-specific gene expression. The underlying mechanisms are thought to mirror, at least in part, the repertoire of regulatory mechanisms controlling mammalian cell differentiation.

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