UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation

Militti, Cristina; Maenner, Sylvain; Becker, Peter B. und Gebauer, Fátima (2014): UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation. In: Nature Communications, Bd. 5, 4762

Abstract

Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 2041-1723
• Sprache: Englisch