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Militti, Cristina; Maenner, Sylvain; Becker, Peter B. ORCID logoORCID: https://orcid.org/0000-0001-7186-0372 and Gebauer, Fátima (2014): UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation. In: Nature Communications, Vol. 5, 4762 [PDF, 2MB]

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Abstract

Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.

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