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Mahlich, Jörg; Bogner, Johannes R.; Tomeczkowski, Jörg and Stoll, Matthias (2015): Treatment strategies for treatment naive HIV patients in Germany: evidence from claims data. In: Springerplus, Vol. 4, 306 [PDF, 998kB]


A recent observational study of HIV patients in Germany suggests that treatment naive patients that are in a more advanced stage of their disease are more likely to receive a treatment regimen based on a boosted protease inhibitor (PI/r) compared with a non-nucleoside reverse-transcriptase-inhibitor (NNRTI) base regimen. To validate those results we analysed claims data of seven German sickness funds from 2009 to 2012 with approximately 4 million beneficiaries. Patients in a more advanced disease state (CDC class C) had a higher likelihood to receive a PI/r based regime rather than a NNRTI based regimen as their initial treatment. There was also a significant correlation between PI/r based regimen and number of comorbidities but not with age. Our results confirm a highly significant relationship between being in a more severe stage of HIV disease and a PI/r based treatment regimen.

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