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Scherer, Kai; Willer, Konstantin; Gromann, Lukas; Birnbacher, Lorenz; Braig, Eva; Grandl, Susanne; Sztrokay-Gaul, Aniko; Herzen, Julia; Mayr, Doris; Hellerhoff, Karin and Pfeiffer, Franz (2015): Toward Clinically Compatible Phase-Contrast Mammography.
In: PLOS ONE 10(6), e0130776 [PDF, 4MB]

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Phase-contrast mammography using laboratory X-ray sources is a promising approach to overcome the relatively low sensitivity and specificity of clinical, absorption-based screening. Current research is mostly centered on identifying potential diagnostic benefits arising from phase-contrast and dark-field mammography and benchmarking the latter with conventional state-of-the-art imaging methods. So far, little effort has been made to adjust this novel imaging technique to clinical needs. In this article, we address the key points for a successful implementation to a clinical routine in the near future and present the very first dose-compatible and rapid scan-time phase-contrast mammograms of both a freshly dissected, cancer-bearing mastectomy specimen and a mammographic accreditation phantom.

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