In: PLOS Genetics
11(5), UNSP e1005223
[PDF, 1MB]
Abstract
The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated variants may operate in a cell-type specific manner, eQTL datasets for such cell-types may not always be available. We performed a genome-environment interaction (GxE) meta-analysis on data from 5, 683 samples to infer the cell type specificity of whole blood cis-eQTLs. We demonstrate that this method is able to predict neutrophil and lymphocyte specific cis-eQTLs and replicate these predictions in independent cell-type specific datasets. Finally, we show that SNPs associated with Crohn's disease preferentially affect gene expression within neutrophils, including the archetypal NOD2 locus.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin > Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
URN: | urn:nbn:de:bvb:19-epub-34297-9 |
ISSN: | 1553-7390 |
Sprache: | Englisch |
Dokumenten ID: | 34297 |
Datum der Veröffentlichung auf Open Access LMU: | 15. Feb. 2017, 16:03 |
Letzte Änderungen: | 04. Nov. 2020, 13:12 |