Pruenster, Monika; Kurz, Angela R. M.; Chung, Kyoung-Jin; Cao-Ehlker, Xiao; Bieber, Stephanie; Nussbaum, Claudia F.; Bierschenk, Susanne; Eggersmann, Tanja K.; Rohwedder, Ina; Heinig, Kristina; Immler, Roland; Moser, Markus; Koedel, Uwe; Gran, Sandra; McEver, Rodger P.; Vestweber, Dietmar; Verschoor, Admar; Leanderson, Tomas; Chavakis, Triantafyllos; Roth, Johannes; Vogl, Thomas; Sperandio, Markus (2015): Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion. In: Nature Communications, Vol. 6, 6915 |
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Abstract
Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in the leukocyte adhesion cascade. We show that E-selectin-PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 secretion. Released MRP8/14 in turn activates a TLR4-mediated, Rap1-GTPase-dependent pathway of rapid beta 2 integrin activation in neutrophils. This extracellular activation loop reduces leukocyte rolling velocity and stimulates adhesion. Thus, we identify Mrp8/14 and TLR4 as important modulators of the leukocyte recruitment cascade during inflammation in vivo.
Item Type: | Journal article |
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Faculties: | Medicine > Institute of Cardiovascular Physiology and Pathophysiology |
Subjects: | 600 Technology > 610 Medicine and health |
URN: | urn:nbn:de:bvb:19-epub-34347-2 |
ISSN: | 2041-1723 |
Language: | English |
ID Code: | 34347 |
Deposited On: | 15. Feb 2017 16:04 |
Last Modified: | 04. Nov 2020 13:12 |
- BASE
- Pruenster, Monika
- Kurz, Angela R. M.
- Chung, Kyoung-Jin
- Cao-Ehlker, Xiao
- Bieber, Stephanie
- Nussbaum, Claudia F.
- Bierschenk, Susanne
- Eggersmann, Tanja K.
- Rohwedder, Ina
- Heinig, Kristina
- Immler, Roland
- Moser, Markus
- Koedel, Uwe
- Gran, Sandra
- McEver, Rodger P.
- Vestweber, Dietmar
- Verschoor, Admar
- Leanderson, Tomas
- Chavakis, Triantafyllos
- Roth, Johannes
- Vogl, Thomas
- Sperandio, Markus
- Google Scholar
- Pruenster, Monika
- Kurz, Angela R. M.
- Chung, Kyoung-Jin
- Cao-Ehlker, Xiao
- Bieber, Stephanie
- Nussbaum, Claudia F.
- Bierschenk, Susanne
- Eggersmann, Tanja K.
- Rohwedder, Ina
- Heinig, Kristina
- Immler, Roland
- Moser, Markus
- Koedel, Uwe
- Gran, Sandra
- McEver, Rodger P.
- Vestweber, Dietmar
- Verschoor, Admar
- Leanderson, Tomas
- Chavakis, Triantafyllos
- Roth, Johannes
- Vogl, Thomas
- Sperandio, Markus