Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy

Reznicek, Lukas; Kolb, Jan P.; Klein, Thomas; Mohler, Kathrin J.; Wieser, Wolfgang; Huber, Robert; Kernt, Marcus; Märtz, Josef und Neubauer, Aljoscha S. (2015): Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy. In: Journal of Diabetes Research, 305084

Abstract

Purpose. To evaluate the feasibility of wide-fieldMegahertz (MHz) OCT imaging in patients with diabetic retinopathy. Methods. A consecutive series of 15 eyes of 15 patients with diagnosed diabetic retinopathy were included. All patients underwent Megahertz OCT imaging, a close clinical examination, slit lamp biomicroscopy, and funduscopic evaluation. To acquire densely sampled, wide-field volumetric datasets, an ophthalmic 1050nm OCT prototype system based on a Fourier-domain mode-locked (FDML) laser source with 1.68MHz A-scan rate was employed. Results. We were able to obtain OCT volume scans from all included 15 patients. Acquisition time was 1.8 seconds. Obtained volume datasets consisted of 2088 x 1044 A-scans of 60 degrees of view. Thus, reconstructed en face images had a resolution of 34.8 pixels per degree in x-axis and 17.4 pixels per degree. Due to the densely sampled OCT volume dataset, postprocessed customized cross-sectional B-frames through pathologic changes such as an individual microaneurysm or a retinal neovascularization could be imaged. Conclusions. Wide-field Megahertz OCT is feasible to successfully image patients with diabetic retinopathy at high scanning rates and a wide angle of view, providing information in all three axes. The Megahertz OCT is a useful tool to screen diabetic patients for diabetic retinopathy.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 2314-6745
• Sprache: Englisch