Synthetic approaches towards alkaloids bearing α-tertiary amines

Hager, Anastasia; Vrielink, Nina; Hager, Dominik; Lefranc, Julien und Trauner, Dirk (2016): Synthetic approaches towards alkaloids bearing α-tertiary amines. In: Natural Product Reports, Bd. 33, Nr. 3: S. 491-522

Abstract

Alkaloids account for some of the most beautiful and biologically active natural products. Although they are usually classified along biosynthetic criteria, they can also be categorized according to certain structural motifs. Amongst these, the α-tertiary amine (ATA), i.e. a tetrasubstituted carbon atom surrounded by three carbons and one nitrogen, is particularly interesting. A limited number of methods have been described to access this functional group and fewer still are commonly used in synthesis. Herein, we review some approaches to asymmetrically access ATAs and provide an overview of alkaloid total syntheses where those have been employed.

• Dokumententyp: Zeitschriftenartikel
• Publikationsform: Publisher's Version
• Fakultät: Chemie und Pharmazie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0265-0568
• Allianz-/Nationallizenz: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
• Bemerkung: First published online 01 Dec 2015
• Sprache: Englisch