Synthetic approaches towards alkaloids bearing α-tertiary amines

Hager, Anastasia; Vrielink, Nina; Hager, Dominik; Lefranc, Julien and Trauner, Dirk (2016): Synthetic approaches towards alkaloids bearing α-tertiary amines. In: Natural Product Reports, Vol. 33, No. 3: pp. 491-522

Abstract

Alkaloids account for some of the most beautiful and biologically active natural products. Although they are usually classified along biosynthetic criteria, they can also be categorized according to certain structural motifs. Amongst these, the α-tertiary amine (ATA), i.e. a tetrasubstituted carbon atom surrounded by three carbons and one nitrogen, is particularly interesting. A limited number of methods have been described to access this functional group and fewer still are commonly used in synthesis. Herein, we review some approaches to asymmetrically access ATAs and provide an overview of alkaloid total syntheses where those have been employed.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 0265-0568
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Annotation: First published online 01 Dec 2015
• Language: English