A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Broichhagen, Johannes; Frank, J. A.; Johnston, N. R.; Mitchell, R. K.; Šmid, K.; Marchetti, P.; Bugliani, M.; Rutter, Guy A.; Trauner, Dirk and Hodson, David J. (2015): A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function. In: Chemical Communications, Vol. 51, No. 27: pp. 6018-6021

Abstract

Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push–pull system.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1359-7345
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Annotation: First published online 26 Feb 2015
• Language: English