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Aitken, Alastair; Collinge, D. B.; Heusden, B. P. H. van; Isobe, T.; Roseboom, P. H.; Rosenfeld, G. and Soll, Jürgen (1992): 14-3-3 proteins. a highly conserved, widespread family of eukaryotic proteins. In: Trends in Biochemical Sciences, Vol. 17, No. 12: pp. 498-501 [PDF, 723kB]


A family of proteins known as 14-3-3 is currently receiving increased attention by investigators studying a broad range of biological systems, including plants and invertebrates. The outstanding feature of this family is the extraordinarily high sequence conservation observed. Current thinking indicates that these proteins may function as regulators in signal tranduction/phosphorylation mechanisms.

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