Stereospecificity of cinnamyl alcohol dehydrogenase and synthesis of stereospecifically labelled coniferyl alcohol

Klischies, Martina; Stöckigt, Joachim und Zenk, Meinhart H. (1978): Stereospecificity of cinnamyl alcohol dehydrogenase and synthesis of stereospecifically labelled coniferyl alcohol. In: Phytochemistry, Bd. 17, Nr. 9: S. 1523-1525

Abstract

Using horse liver alcohol dehydrogenase, stereospecifically tritiated (R)- and (S)-(γ-3H)-coniferyl alcohol was synthesized. Using both of these substrates it was demonstrated that cinnamyl alcohol dehydrogenase from lignifying Forsythia tissue specifically removes the pro-R-hydrogen atom of coniferyl alcohol in the oxidation to the aldehyde. This also means that in the reverse reaction the A-hydrogen of NADPH is transferred to the Re-site of coniferyl aldehyde.

• Dokumententyp: Zeitschriftenartikel
• Keywords: Forsythia suspensa; Oleaceae; cinnamyl alcohol oxido-reductase; cinnamyl alcohol; cinnamyl aldehydes; stereospecificity
• Fakultät: Chemie und Pharmazie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie