Shifted intrinsic connectivity of central executive and salience network in borderline personality disorder

Doll, Anselm; Sorg, Christian; Manoliu, Andrei; Wöller, Andreas; Meng, Chun; Förstl, Hans; Zimmer, Claus; Wohlschläger, Afra M. und Riedl, Valentin (October 2013): Shifted intrinsic connectivity of central executive and salience network in borderline personality disorder. In: Frontiers in Human Neuroscience, Vol. 7, 727

Abstract

Borderline personality disorder (BPD) is characterized by ``stableinstability'' of emotions and behavior and their regulation. This emotional and behavioral instability corresponds with a neurocognitive triple network model of psychopathology, which suggests that a berrant emotional saliency and cognitive control is associated with a berrant interaction across three intrinsic connectivity networks i.e., these alience network (SN), default mode network (DMN), and central executive network (CEN)]. The objective of the current study was to investigate whether and how such triple network intrinsic functional connectivity (iFC) is changed inpatients with BPD. We acquired resting-state functional magnetic resonance imaging (rs-fMRI) data from 14 patients with BPD and 16 healthy controls. High-odel order independent component analysis was used to extracts patio temporal patterns of on going, coherent blood-oxygen-level-dependent signal fluctuations fromrs-f MRI data. Main outcome measures wereiFC within networks (intra-iFC) and between networks (i. e., network time course correlation inter-iFC). Aberrant intra-iFC was found inpatients `DMN, SN, and CEN, consistent with previous findings. While patients'inter-iFCof the CEN was decreased, inter-iFCof the SN was increased. Inparticular, abalance index reflecting the relationship of CEN and SN-inter-iFC across networkswas strongly shifted from CEN to SNconnectivity inpatients. Results provide first preliminary evidence for aberran triple network iFCinBPD. Our data suggest as hift of inter- network iFC from networks involve dincognitive control to those of emotion related activity in BPD, potentially reflecting the persistent instablity of emotion regulation in patients.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Keywords: resting-statefunctionalconnectivity; brainnetworks; centralexecutivenetwork; defaultmodenetwork; salience network; brainconnectivity; large-scalenetworks; triplenetworkhypothesis
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1662-5161
• Place of Publication: PO BOX 110, LAUSANNE, 1015, SWITZERLAND
• Language: English