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Abstract
Twenty-three years ago, numb was identified as a critical regulator in Drosophila sensory organ precursor cell asymmetric divisions. Beyond the recently recognized role in carcinogenesis, Numb seems to be important in Alzheimer's disease. This assertion comes from the involvement in various processes such as synapse morphogenesis, amyloid precursor protein trafficking, notch signaling, and neurogenesis. The purpose of the present minireview is to provide the current picture of Numb's participation in mechanisms underlying Alzheimer's disease pathogenesis and emphasize potential aspects for future research.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Keywords: | Alzheimer's disease; numb; neurogenesis; notch signaling |
| Fakultät: | Medizin > Physiologisches Institut |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| URN: | urn:nbn:de:bvb:19-epub-36836-8 |
| ISSN: | 1662-453X |
| Ort: | PO BOX 110, LAUSANNE, 1015, SWITZERLAND |
| Sprache: | Englisch |
| Dokumenten ID: | 36836 |
| Datum der Veröffentlichung auf Open Access LMU: | 05. Apr. 2017, 17:09 |
| Letzte Änderungen: | 04. Nov. 2020, 13:14 |
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