
Abstract
Twenty-three years ago, numb was identified as a critical regulator in Drosophila sensory organ precursor cell asymmetric divisions. Beyond the recently recognized role in carcinogenesis, Numb seems to be important in Alzheimer's disease. This assertion comes from the involvement in various processes such as synapse morphogenesis, amyloid precursor protein trafficking, notch signaling, and neurogenesis. The purpose of the present minireview is to provide the current picture of Numb's participation in mechanisms underlying Alzheimer's disease pathogenesis and emphasize potential aspects for future research.
Item Type: | Journal article |
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Keywords: | Alzheimer's disease; numb; neurogenesis; notch signaling |
Faculties: | Medicine > Institute of Physiology |
Subjects: | 600 Technology > 610 Medicine and health |
URN: | urn:nbn:de:bvb:19-epub-36836-8 |
ISSN: | 1662-453X |
Place of Publication: | PO BOX 110, LAUSANNE, 1015, SWITZERLAND |
Language: | English |
Item ID: | 36836 |
Date Deposited: | 05. Apr 2017, 17:09 |
Last Modified: | 04. Nov 2020, 13:14 |