Langhals, Heinz; Mergelsberg, Ingrid; Rüchardt, Christoph
Synthesis of 13C—O-labelled tertiary alkanoic acids by the Koch-haaf-reaction.
In: Tetrahedron Letters, Vol. 22, No. 25: pp. 2365-2366
Good yields of tertiary alkanoic acids are obtained from the Koch-Haaf-synthesis even when only stoichiometric amounts of carbinol and HCOOH are used. This offers a new approach to 13CO-labelled tertiary alkanoic acids. - An excess of HCOOH is generally used in the Koch-Haaf-synthesis1) of carboxylic acids from carbinols and HCOOH in conc. H2SO4.