Alkylation of ketones by use of solid KOH in dimethyl sulfoxide

Langhals, Elke und Langhals, Heinz (1990): Alkylation of ketones by use of solid KOH in dimethyl sulfoxide. In: Tetrahedron Letters, Bd. 31, Nr. 6: S. 859-862

Abstract

A mixture of solid KOH in dimethyl sulfoxide has a strong basicity, but only a low nucleophilicity and is used for methylation of ketones. With this simple and inexpensive reagent complete methylation with yields up to 90% can be achieved.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie