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Langhals, Elke and Langhals, Heinz ORCID logoORCID: https://orcid.org/0000-0002-8038-4547 (1990): Alkylation of ketones by use of solid KOH in dimethyl sulfoxide. In: Tetrahedron Letters, Vol. 31, No. 6: pp. 859-862 [PDF, 206kB]


A mixture of solid KOH in dimethyl sulfoxide has a strong basicity, but only a low nucleophilicity and is used for methylation of ketones. With this simple and inexpensive reagent complete methylation with yields up to 90% can be achieved.

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