Alkylation of ketones by use of solid KOH in dimethyl sulfoxide

Langhals, Elke and Langhals, Heinz (1990): Alkylation of ketones by use of solid KOH in dimethyl sulfoxide. In: Tetrahedron Letters, Vol. 31, No. 6: pp. 859-862

Abstract

A mixture of solid KOH in dimethyl sulfoxide has a strong basicity, but only a low nucleophilicity and is used for methylation of ketones. With this simple and inexpensive reagent complete methylation with yields up to 90% can be achieved.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry