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Ferre, Natalia; Rubio-Torrents, Carmen; Luque, Veronica; Closa-Monasterolo, Ricardo; Grote, Veit; Koletzko, Berthold; Socha, Piotr; Gruszfeld, Dariusz; Langhendries, Jean Paul; Sengier, Anne; Verduci, Elvira and Escribano, Joaquin (2017): Influence of Feeding Types during the First Months of Life on Calciuria Levels in Healthy Infants. A Secondary Analysis from a Randomized Clinical Trial. In: Annals of nutrition & metabolism, Vol. 70, No. 2: pp. 132-139

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BACKGROUND/AIMS: Dietary factors can modify calciuria. We aim to investigate urinary calcium excretion in healthy infants according to their protein. METHODS: Secondary data analysis from a randomized clinical trial where healthy term infants were randomized after birth to a higher (HP) or lower (LP) protein content formula that was consumed until age 1 year. A non-randomized group of breastfed (BF) infants was used for reference. Anthropometry, dietary intakes and calciuria (calcium/creatinine ratios) from spot urine samples were assessed at ages 3 and 6 months. At 6 months, the kidney volumes were assessed using ultrasonography, and the serum urea and creatinine levels were determined. RESULTS: BF infants showed the highest calciuria levels, followed by the HP and the LP groups (p < 0.001 for all comparisons). Either protein intakes or formula types modulated the calciuria in linear regression models adjusted for other influencing dietary factors. The usual cut-off values classified 37.8% (BF), 16.8% (HP) and 4.9% (LP) of the infants as hypercalciuric. CONCLUSIONS: Feeding types during the first months of life affect calciuria, with BF infants presenting the highest levels. We propose new cut-off values, based on feeding types, to prevent the overestimation in hypercalciuria diagnoses among BF infants.

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