Diastereoselective synthesis of β- and γ2-muurolene. A carbocationic pathway from mono- to sesquiterpenes

Rahman, Azizur; Klein, Herbert; Dressel, Jürgen und Mayr, Herbert (1988): Diastereoselective synthesis of β- and γ2-muurolene. A carbocationic pathway from mono- to sesquiterpenes. In: Tetrahedron, Bd. 44, Nr. 19: S. 6041-6045

Abstract

The Lewis acid catalysed addition of the piperityl chlorides 6 to isoprene yields adduct 7, which undergoes a cis-stereoselective cyclisation to give the diastereoisomeric muurolene monohydrochlorides 8. Treatment with potassium tert-butoxide affords β- and γ2- muurolene 2.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie