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Maso, L. dal; Kowalska, A.; Virdone, S.; Mallone, S.; Amash, H.; Angelis, R. de; Pacini, F.; Tavilla, A.; Serraino, D.; Dijk, B.A.C. van; Chirlaque, M.D.; Colonna, M.; Capocaccia, R.; Larrañaga, N.; Rubió-Casadevall, J.; Agius, D.; Ardanaz, E.; Schubert-Fritschle, Gabriele (2017): Survival of 86,690 patients with thyroid cancer: a population-based study in 29 European countries from EUROCARE-5. In: European Journal of Cancer, Vol. 77: pp. 140-152
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Abstract

BACKGROUND Incidence rates of thyroid cancer (TC) increased in several countries during the last 30 years, while mortality rates remained unchanged, raising important questions for treatment and follow-up of TC patients. This study updates population-based estimates of relative survival (RS) after TC diagnosis in Europe by sex, country, age, period~and histology. METHODS Data from 87 cancer registries in 29 countries were extracted from the EUROCARE-5 dataset. One- and 5-year RS were estimated using the cohort approach for 86,690 adult TC patients diagnosed in 2000-2007 and followed-up to 12/31/2008. RS trends in 1999-2007 and 10-year RS in 2005-2007 were estimated using the period approach. RESULTS In Europe 2000-2007, 5-year RS after TC was 88% in women and 81% in men. Survival rates varied by country and were strongly correlated (Pearson \textgreekr~=~75%) with country-specific incidence rates. Five-year RS decreased with age (in women from \textgreater95% at age 15-54 to 57% at age 75+), from 98% in women and 94% in men with papillary TC to 14% in women and 12% in men with anaplastic TC. Proportion of papillary TC~varied by country and increased over time, while survival rates were similar across areas and periods. In 1999-2007, 5-year RS increased by five percentage points for all TCs~but only by two for papillary~and by four for follicular TC. Ten-year RS in 2005-2007 was 89% in women and 79% in men. CONCLUSIONS The reported increasing TC survival trend and differences by area are mainly explained by the varying histological case-mix of cases.