Mechanics and Activation of Unconventional Myosins

Batters, Christopher und Veigel, Claudia (2016): Mechanics and Activation of Unconventional Myosins. In: Traffic, Vol. 17, No. 8: pp. 860-871

Abstract

Many types of cellular motility are based on the myosin family of motor proteins ranging from muscle contraction to exo- and endocytosis, cytokinesis, cell locomotion or signal transduction in hearing. At the center of this wide range of motile processes lies the adaptation of the myosins for each specific mechanical task and the ability to coordinate the timing of motor protein mobilization and targeting. In recent years, great progress has been made in developing single molecule technology to characterize the diverse mechanical properties of the unconventional myosins. Here, we discuss the basic mechanisms and mechanical adaptations of unconventional myosins, and emerging principles regulating motor mobilization and targeting.

• Item Type: Journal article
• Faculties: Medicine
• Research Centers: GeoBio-Center
• Subjects: 600 Technology > 610 Medicine and health; 500 Science > 500 Science
• ISSN: 1398-9219
• Language: English