FUScinating insights into motor neuron degeneration

Dormann, Dorothee (2016): FUScinating insights into motor neuron degeneration. In: Embo Journal, Bd. 35, Nr. 10: S. 1015-1017

Abstract

Point mutations in FUS cause amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease-but do they do that by a loss of the protein's normal function, or by endowing it with novel toxic functions, or both? In this issue of The EMBO Journal, Scekic-Zahirovic et al (2016) report that mutant FUS, but not the complete loss of FUS, triggers motor neuron degeneration in mice, arguing for a toxic gain-of-function mechanism.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0261-4189
• Sprache: Englisch