FUScinating insights into motor neuron degeneration

Dormann, Dorothee (2016): FUScinating insights into motor neuron degeneration. In: Embo Journal, Vol. 35, No. 10: pp. 1015-1017

Abstract

Point mutations in FUS cause amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease-but do they do that by a loss of the protein's normal function, or by endowing it with novel toxic functions, or both? In this issue of The EMBO Journal, Scekic-Zahirovic et al (2016) report that mutant FUS, but not the complete loss of FUS, triggers motor neuron degeneration in mice, arguing for a toxic gain-of-function mechanism.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0261-4189
• Language: English