Dormann, Dorothee (2016): FUScinating insights into motor neuron degeneration. In: Embo Journal, Vol. 35, No. 10: pp. 1015-1017 |
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Abstract
Point mutations in FUS cause amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease-but do they do that by a loss of the protein's normal function, or by endowing it with novel toxic functions, or both? In this issue of The EMBO Journal, Scekic-Zahirovic et al (2016) report that mutant FUS, but not the complete loss of FUS, triggers motor neuron degeneration in mice, arguing for a toxic gain-of-function mechanism.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 0261-4189 |
Language: | English |
ID Code: | 43664 |
Deposited On: | 27. Apr 2018 08:04 |
Last Modified: | 04. Nov 2020 13:19 |
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