Immune Mechanisms in Pulmonary Fibrosis

Kolahian, Saeed; Fernandez, Isis E.; Eickelberg, Oliver; Hartl, Dominik (2016): Immune Mechanisms in Pulmonary Fibrosis. In: American Journal of Respiratory Cell and Molecular Biology, Vol. 55, No. 3: pp. 309-322

Abstract

Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and progressive disease with high mortality and limited therapeutic options. Excessive deposition of extracellular matrix proteins results in fibrotic remodeling, alveolar destruction, and irreversible loss of lung function. Both innate and adaptive immune mechanisms contribute to fibrogenesis at several cellular and noncellular levels. Here, we summarize and discuss the role of immune cells (T cells, neutrophils, macrophages, and fibrocytes) and soluble mediators (cytokines and chemokines) involved in pulmonary fibrosis, pointing toward novel immune-based therapeutic strategies in the field.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1044-1549
• Language: English