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Zhang, Wen-Peng; Wang, Ming-Liang; Lu, Ai-Guo; Zhao, Jing-Kun; Yin, Shuai; Beatrice, Rauter; Schiergens, Tobias S.; Feng, Hao (2016): Biomarkers and long-term prognosis of colorectal schistosomiasis-associated rectosigmoid cancer: a retrospective study. In: International Journal of Clinical and Experimental Pathology, Vol. 9, No. 2: pp. 1005-1013
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Abstract

Aim: This study is to assess the association between the potential long-term effects of previous schistosoma infection and rectosigmoid cancer. Methods: From November 2006 to May 2011, 25 patients who had rectosigmoid carcinoma combined with colorectal schistosomiasis (SSC), 217 patients with non-schistosomiasis rectosigmoid carcinoma (NSC), 19 colorectal schistosomiasis (CS) were included. Tumor characteristics, pre-operative investigations, tumor pathological examinations and postoperative courses were evaluated. Results: There was no significant difference in overall survival rate between the SSC and NSC groups. Levels of CEA, AFP and CA19-9 did not differ among three groups;CA19-9 values were significantly larger in SSC group than those in NSC group. Levels of CA-125 were significantly higher (P<0.0001) in CS group compared to the other two groups, but no significant difference could be observed between NSC and SSC groups. Concerning the biopsy staining, CA125 was upregulated in CS and SSC group, significantly stronger staining was observed. Conclusions: For those who travelled from or lived in endemic areas, elevated serum CA19-9 and CA-125 may be signals for those who have colorectal lesions and infested water contact history to go through the circumival precipintin test (COPT), for rectosigmoid cancer patients whose biopsy is CA-125 positive, rectosigmoid carcinoma combined with colorectal schistosomiasis (SSC) should be considered. However, schistosomiasis was not statistically significantly correlated with overall survival in patients suffering rectosigmoid cancer.