Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche

Di Scala, Marianna und Hidalgo, Andrés (2016): Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche. In: Cell Stem Cell, Bd. 19, Nr. 3: S. 284-286

Abstract

Successful hematopoietic regeneration demands preservation of stemness while enabling expansion and differentiation into blood lineages. Now, Silberstein et al. (2016) and Goncalves et al. (2016) identify a ribonuclease secreted by proximal niche cells that simultaneously drives quiescence of HSCs and proliferation of myeloid progenitors and dramatically enhances hematopoietic recovery after HSC transplantation.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1934-5909
• Sprache: Englisch