Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche

Di Scala, Marianna und Hidalgo, Andrés (2016): Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche. In: Cell Stem Cell, Vol. 19, No. 3: pp. 284-286

Abstract

Successful hematopoietic regeneration demands preservation of stemness while enabling expansion and differentiation into blood lineages. Now, Silberstein et al. (2016) and Goncalves et al. (2016) identify a ribonuclease secreted by proximal niche cells that simultaneously drives quiescence of HSCs and proliferation of myeloid progenitors and dramatically enhances hematopoietic recovery after HSC transplantation.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1934-5909
• Language: English