Kinetics of the phthalate metabolites mono-2-ethylhexyl phthalate (MEHP) and mono-n-butyl phthalate (MnBP) in male subjects after a single oral dose

Mittermeier, Astrid; Völkel, Wolfgang und Fromme, Hermann (2016): Kinetics of the phthalate metabolites mono-2-ethylhexyl phthalate (MEHP) and mono-n-butyl phthalate (MnBP) in male subjects after a single oral dose. In: Toxicology Letters, Bd. 252: S. 22-28

Abstract

Humans have been exposed to dialkyl ortho-phthalates for decades. Due to degradation the phthalate monoesters, responsible for the toxic effects, are additionally found in environmental media as well as food samples. Nevertheless, the toxicokinetic properties of the monoesters are not known. Therefore, metabolism of the phthalate monoesters mono-2-ethylhexyl phthalate (MEHP) and mono-n-butyl phthalate (MnBP) was studied in four male volunteers (23-58 years of age) after ingestion of a single dose of 50 mu g/kg bw D-4-MEHP or 10 mu g/kg bw D-4-MnBP. The main metabolites in urine were determined up to 46 h after administration. In the MEHP-study, more than 90% of each metabolite appeared in the urine within the first 22 h, and the average excreted amount of D-4-MEHP and its four secondary metabolites was 62% of the administered dose. The highest value of 15% was observed for mono-2-ethyl-5-carboxy-pentyl phthalate (D-4-5cx-MEPP). The mean elimination half-life of D-4-MEHP was estimated to be 3.5 +/- 1.4 h. In the MnBP-study, the total recovered values of D-4-MnBP and its secondary metabolites ranged from 52% to 130%. The monoester itself, with a half-life of 1.9 +/- 0.5 h, accounted for the majority of the ingested dose (92%), while the secondary metabolites D-4-mono-3-hydroxy-n-butyl phthalate (D-4-3OH-MnBP) and D-4-3-carboxy-mono-propyl phthalate (D-4-3cx-MPP) represented only 7.1% and 1.0% of the ingested dose, respectively. Overall, this study determined that the kinetics of the phthalate monoesters MEHP and MnBP after oral dosage are comparable to the properties of their diesters. (C) 2016 ELSEVIER. All rights reserved.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0378-4274
• Sprache: Englisch