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Stuelpnagel, C. von; Winkler, P.; Koch, J.; Zeches-Kansy, C.; Schöttler-Glas, A.; Wolf, G.; Niller, H. H.; Staudt, M.; Kluger, G.; Rostasy, K. (2016): MRI-imaging and clinical findings of eleven children with tick-borne encephalitis and review of the literature. In: European Journal of Paediatric Neurology, Vol. 20, No. 1: pp. 45-52
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Objectives: The incidence of tick-borne encephalitis (TBE) is increasing in many countries. Magnetic resonance imaging (MRI) in the course of TBE is not regularly performed in children. The aim of our study was evaluating MRI-findings of children and adolescents with TBE. Patients and methods: Retrospective evaluation of the charts and MRIs of patients who had been treated for TBE in the four participating hospitals in the last twenty years. Results: 11 patients (5 male;age at TBE 3 weeks-15 9/12 years;mean 104.9 months) were included. MRI (within the first week after admission) revealed symmetric or asymmetric T2-hyperintensities in both thalami in 7/11 patients with additional bilateral lesions in putamen and/or caudate nucleus in 3 patients, and additional cortical lesions in 2 patients. Our youngest patient presented with T2-hyperintensities affecting the whole left cerebral hemisphere including white and grey matter and both cerebellar hemispheres. One patient had a minimal reversible T2-hyperintensity in the splenium of the corpus callosum (RHSCC). 3/11 patients had a normal MRI. 4/11 patients showed complete neurological recovery (2/4 with a normal MRI, RHSCC patient). 6/11 children survived with significant sequelae: hemiparesis (n = 4);cognitive deficits (n = 4);pharmacoresistant epilepsy (n = 2). One patient died of a malignant brain edema. Discussion: A spectrum of MRI findings can be found in children with TBE, often showing involvement of the subcortical deep grey matter structures. In children presenting with a meningoencephalitis and bilateral thalamic involvement TBE should be included in the differential diagnosis. (C) 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.