PET imaging in extratemporal epilepsy requires consideration of electroclinical findings

Hartl, Elisabeth; Rémi, Jan; Vollmar, Christian; Goc, Joanna; Loesch, Anna Mira; Rominger, Axel und Noachtar, Soheyl (2016): PET imaging in extratemporal epilepsy requires consideration of electroclinical findings. In: Epilepsy Research, Bd. 125: S. 72-76

Abstract

Objective: The study aimed to assess the relevance of interictal temporal glucose hypometabolism in patients with extratemporal epilepsy (ETE) by analyzing its association with a seizure semiology suggestive for temporal seizure involvement and the presence of temporal interictal epileptiform discharges (IEDs). Methods: We retrospectively reviewed the database of our epilepsy monitoring unit for patients with ETE, in whom long-term EEG-video-monitoring and [F-18] fluorodeoxyglucose positron emission tomography (FDG-PET) had been performed. The localization of IEDs and the glucose hypometabolism were compared. Results: Almost half (46%) of the 63 ETE patients had IEDs localized in the temporal lobe. Most patients (87.5%;7/8) with temporal IEDs and an ipsitemporal hypometabolism showed seizure semiology suggestive of temporal or limbic system involvement in contrast to only 31.0% (9/29, p = 0.01) in patients without temporal IEDs nor temporal hypometabolism. Those patients also showed an ictal seizure pattern spread into the ipsitemporal lobe, compared with 75.9% (22/29, n.s.) in patients without temporal IEDs nor temporal hypometabolism. Both, extratemporal (ipsilateral in 82.1%;23/28 patients) and temporal (ipsilateral in 78.6%;11/14 patients) hypometabolism significantly (p < 0.05) lateralized to the epileptogenic hemisphere. Conclusion: The common temporal glucose hypometabolism in ETE patients reflects a remote epileptic dysfunction arising from extratemporal epileptogenic zones. Thus, interpretation of interictal FDG-PET results requires consideration of EEG results and seizure semiology to avoid false localization particularly in non-lesional epilepsy. (C) 2016 Elsevier B.V. All rights reserved.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0920-1211
• Sprache: Englisch